Genesis 4 v16-26 contrast two family lines. From Cain came a cultured but morally corrupt line, and from Seth, Eve's newest son, came a godly line which began to call upon the name of the LORD.

Genesis 4:16–26

16 Then Cain went away from the presence of the LORD and settled in the land of Nod,¹ east of Eden.

17 Cain knew his wife, and she conceived and bore Enoch. When he built a city, he called the name of the city after the name of his son, Enoch. 18 To Enoch was born Irad, and Irad fathered Mehujael, and Mehujael fathered Methushael, and Methushael fathered Lamech. 19 And Lamech took two wives. The name of the one was Adah, and the name of the other Zillah. 20 Adah bore Jabal; he was the father of those who dwell in tents and have livestock. 21 His brother’s name was Jubal; he was the father of all those who play the lyre and pipe. 22 Zillah also bore Tubal-cain; he was the forger of all instruments of bronze and iron. The sister of Tubal-cain was Naamah.

23 Lamech said to his wives:

  “Adah and Zillah, hear my voice;
    you wives of Lamech, listen to what I say:
  I have killed a man for wounding me,
    a young man for striking me.
24   If Cain’s revenge is sevenfold,
    then Lamech’s is seventy-sevenfold.”

25 And Adam knew his wife again, and she bore a son and called his name Seth, for she said, “God has appointed² for me another offspring instead of Abel, for Cain killed him.” 26 To Seth also a son was born, and he called his name Enosh. At that time people began to call upon the name of the LORD.

Footnotes

[1] 4:16 Nod means wandering
[2] 4:25 Seth sounds like the Hebrew for he appointed

(ESV)